My CV
BSc in Biomedical Sciences (UAB)
2014-2018
MSc in Biomedical Research (UPF)
2018-2019
PhD in Immunology (UParisCité)
2019-2023
Laboratory of Cellular Immunology - UAB, Barcelona
(Prof. Dolores Jaraquemada)
2016-2019
Together with D. Jaraquemada and M. Carrascal, I worked in the optimisation of immunopeptidomic methods for the identification of MHC-binding peptides in the context of autoimmunity and cancer.
Immunity and Cancer Unit - Institut Curie, Paris
(Dr. Sebastian Amigorena)
2019-present
In S. Amigorena lab, I worked in the understanding of the non-canonical proteome and its role in cell. Also, I studied how it is seen by the immune system and its potential use in cancer immunotherapy.
Publications
Bonté PE*, Arribas YA*, Merlotti A, Carrascal M, Zhang JV, Zueva E, Binder ZA, Alanio C, Goudot C, Amigorena S. Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides. Cell Rep. 2022 Jun 7;39(10):110916. doi: 10.1016/j.celrep.2022.110916. PMID: 35675780. (*equal contribution)
Merlotti A*, Sadacca B*, Arribas YA*, Houy A, Ngoma M, Goudot C, Rocañín-Arjó S, Lalanne A, Seguin-Givelet A, Lefevre M, Burbage M, Oliveira G, Loew D, Carrascal M, Wu CJ, Lantz O, Stern MH, Girard N, Waterfall JJ, Amigorena DS. Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer. Sci Immunol. 2023 Feb 3;8(80):eabm6359. doi: 10.1126/sciimmunol.abm6359. PMID: 36735774. (*equal contribution)
Burbage M*, Rocañín-Arjó A*, Baudon B, Arribas YA, Merlotti A, Rookhuizen DC, Ye M, Houy A, Burgdorf N, Suarez G, Gros M, Sadacca B, Carrascal M, Garmilla A, Bohec M, Baulande S, Lombard B, Loew D, waterfall JJ, Stern MH, Goudot C, Amigorena DS. Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements. Sci Immunol. 2023 Feb 3;8(80):eabm6360. doi: 10.1126/sciimmunol.abm6360. PMID: 36735776.
Cocozza F. Martin-Jaular L, Lippens L, Di Cicco A, Arribas YA, Dingli F, Richard M, Merle L, Poullet P, Loew D, Lévy D, Hendrix A, Kassiotis G, Joliot A, Tkach M, Théry C. Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells. biorxiv. 2023 Jan 28. doi: 10.1101/2023.01.27.525863
Aran A, Peg V, Rabanal RM, Bernadó C, Zamora E, Molina E, Arribas YA, Arribas J, Pérez J, Roura-Mir C, Carrascal M, Cortés J, Martí M. Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report. Front Immunol. 2021 Nov 16;12:761798. doi: 10.3389/fimmu.2021.761798. PMID: 34868006; PMCID: PMC8637110.
Patents
Amigorena, S; Burbage, M; Houy, A; Waterfall, J; Stern, MH; Sadacca, B; Merlotti, A; Arribas, Y. Immunotherapy targeting tumor neoantigenic peptides. WO2021/043804A1. EP2020074429W. 2020.
Amigorena, S; Burbage, M; Houy, A; Waterfall, J; Stern, MH; Sadacca, B; Merlotti, A; Arribas, Y; Goudot, C. Tumor neoantigenic peptides and uses thereof. WO2022/189639A1. EP21305302A. 2021.
Amigorena, S; Burbage, M; Houy, A; Waterfall, J; Stern, MH; Sadacca, B; Merlotti, A; Goudot, C; Lopez-Lastra, S; Arribas, Y. Transmembrane neoantigenic peptides. WO2022/189620A1. EP21305296A. 2021.
Amigorena, S; Burbage, M; Houy, A; Waterfall, J; Stern, MH; Sadacca, B; Merlotti, A; Arribas, Y; Goudot, C. Tumor neoantigenic peptides. WO 2022/189626A2. EP21305299A. 2021.
Amigorena, S; Merlotti, A; Goudot, C; Bonte PE; Arribas, Y. Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma. 2022.
Oral communications and poster presentations
2022: Flash talk and poster. HUPO-Human Immunopeptidome Project (Oxford). Best Poster Award.
2022: Oral communication. 2nd Meeting of Spanish, French and Portuguese Proteomics Societies (Portugal)
2020: Poster. VIII Congress of Sociedad Española de Proteómica (Oviedo)
2019: Oral communication and poster. EMBO Antigen processing and presentation 10 (Paris)
2018: Poster. B-Debate: Clinical Proteomics (Barcelona)
2018: Poster. 5th European Congress of Immunology (Amsterdam)
2018: Poster. Cellular Biology, Physiology and Immunology UAB journeys (Barcelona). Best Poster Award.
2017: Poster. SPSAS on Mass Spectrometry-based Proteomics (Sao Paulo, Brazil). Best Poster Award.
2017: Poster. Cellular Biology, Physiology and Immunology UAB journeys (Barcelona)
2013: Oral communication. XIth SCAR Biology Symposium (Barcelona)
Fellowships
2019: Sociedad Española de Proteómica (SeProt)
2019-2022: Ligue National Contre Le Cancer
2022-2023: Fondation ARC
References
Sebastian Amigorena, PhD Laboratory of Immunity and Cancer, U932, Institut Curie, Paris. (sebastian.amigorena@curie.fr)
Dolores Jaraquemada, PhD, Prof. Immunology Laboratory of Cellular Immunology, Institut de Biotecnologia i Biomedicina (IBB), Autonomous University of Barcelona. (dolores.jaraquemada@uab.cat)
Montserrat Carrascal, PhD CSIC-UAB Proteomics Laboratory, Faculty of Medicine, Autonomous University of Barcelona (UAB). (montserrat.carrascal.csic@uab.cat)
Joshua Waterfall, PhD Laboratory of Integrative Functional Genomics in Cancer, U830, Institut Curie, Paris. (joshua.waterfall@curie.fr)